Host immune response to infection with porcine circoviruses

Abstract Porcine circovirus type 2 (PCV2), which serves as a major causative agent of PCV2-associated diseases and causes severe loss to the pig industry worldwide, can dysregulate immune response induce immunosuppression in PCV2-infected pigs. Similar PCV2, porcine 3 (PCV3), newly identified swine might be closely associated with dermatitis nephropathy syndrome, reproductive disorder, multisystemic inflammatory responses, also interferes host defense. Interaction between system PCVs is considered crucial determinant pathogenicity Here, we sought briefly discuss current knowledge regarding interaction and/or cells responses better depict viral immunomodulatory capacity, pathogenic mechanisms, future research direction infection PCV2 PCV3.